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GLP-1 is a natural hormone made by our intestinal tract every time we eat. It is deficient in obesity. It decreases appetite and makes us feel full. It helps your body burn rather than store fat by acting on the cells of your pancreas. The GLP-1 agonists are given by once weekly injections. Some sublingual formulations have shown effectiveness as well. Results in some studies are very close to those of gastric sleeve and bariatric surgery. No restrictive diets or intense exercise are required.